Drugs of Abuse Testing Assays

6-Acetylmorphine

AB-PINACA

Amphetamines

  • Immunalysis Amphetamines HEIA

Barbiturates

  • Immunalysis Barbiturates HEIA

Benzodiazepines

Benzoylecgonine (Cocaine Metab.)

  • Immunalysis Benzoylecgonine HEIA

Buprenorphine

Cannabinoids

  • Immunalysis Cannabinoids HEIA

Carisoprodol

  • Immunalysis Carisoprodol HEIA

EDDP

Ethylglucuronide (EtG)

Fentanyl

JWH-018

Ketamine

Meperidine

  • ARK Meperidine Assay
  • Immunalysis Meperidine HEIA

Methamphetamine

  • Immunalysis Methamphetamine HEIA

Methylphenidate-Metabolite

Opiates

  • Immunalysis Opiates HEIA

Oxycodone

  • Immunalysis Oxycodone HEIA

Phencyclidine (PCP)

  • Immunalysis Phencyclidine HEIA

Pregabalin

Tapentadol

  • Immunalysis Tapentadol HEIA

Tramadol

  • ARK Diagnostics Tramadol Assay
  • Immunalysis Tramadol HEIA

UR-144 / XLR-11

Zolpidem

  • Immunalysis Zolpidem HEIA

6-Acetylmorphine (6‑AM) Urine HEIA

The 6-Actylmorphine (6-AM) Urine HEIA is a highly specific assay specifically designed to accurately detect recent heroin abuse. This sensitive test method minimizes false-positive screening results, thus reducing the cost of confirmation testing. Thanks to the innovative rFAB technology (rFAB = antigen-binding fragment), this homogeneous enzyme immunoassay is an excellent tool for distinguishing between samples that are positive due to heroin use and those that test positive due to prescription drugs such as codeine or slow-release morphine (Substitol®), or to the consumption of poppy seed-containing foods.

Assay Characteristics
  • Outstanding specificity and selectivity thanks to rFAB technology
  • Virtually no cross-reactivity to morphine and its metabolites (XR < 0,005%)
  • No significant cross-reactivity to other relevant opiates (such as codeine, dihydrocodeine, & morphine glucuronides)
  • Liquid, ready-to-use reagents, calibrators, and controls – no reconstitution required
  • Application protocols for all major clinical chemistry analyzers
  • Flexible kit sizes for your laboratory’s sample volume requirements
Background
6-Acetylmorphine (6-AM) is an active metabolite of heroin (diacetylmorphine). Due to its extremely short half-life, heroin is quickly converted into 6-AM after ingestion and then further metabolized to morphine or excreted directly via the urine. If the specific heroin metabolite 6-AM is present in a urine sample, this indicates heroin use within the last 24 hours.
In most European countries, methadone or buprenorphine are used as the preferred substitution drugs in the withdrawal treatment of heroin addicts. However, some other countries, such as Germany and Austria, substitute morphine in the form of morphine sulfate (Substitol®). Given the growing importance of substitution therapy with Substitol®, the specific determination of 6‑acetylmorphine as clear evidence of heroin use in the screening procedures used is crucial to reliably detect heroin use or abuse during substitution or withdrawal treatment.

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