Drugs of Abuse Testing Assays
6-Acetylmorphine
AB-PINACA
- ARK AB-PINACA Assay
- Immunalysis Synthetic Cannabinoids-3 HEIA
Amphetamines
- Immunalysis Amphetamines HEIA
Barbiturates
- Immunalysis Barbiturates HEIA
Benzodiazepines
Benzoylecgonine (Cocaine Metab.)
- Immunalysis Benzoylecgonine HEIA
Buprenorphine
Cannabinoids
- Immunalysis Cannabinoids HEIA
Carisoprodol
- Immunalysis Carisoprodol HEIA
EDDP
- ARK EDDP Assay
- Immunalysis EDDP Specific HEIA
Ethylglucuronide (EtG)
Fentanyl
JWH-018
- ARK UR144/JWH-018 Assay
- Immunalysis Synthetic Cannabinoids-1 HEIA
Ketamine
Meperidine
- ARK Meperidine Assay
- Immunalysis Meperidine HEIA
Methamphetamine
- Immunalysis Methamphetamine HEIA
Methylphenidate-Metabolite
Opiates
- Immunalysis Opiates HEIA
Oxycodone
- Immunalysis Oxycodone HEIA
Phencyclidine (PCP)
- Immunalysis Phencyclidine HEIA
Pregabalin
Tapentadol
- Immunalysis Tapentadol HEIA
Tramadol
- ARK Diagnostics Tramadol Assay
- Immunalysis Tramadol HEIA
UR-144 / XLR-11
- ARK UR144/JWH-018 Assay
- Immunalysis Synthetic Cannabinoids-2 HEIA
Zolpidem
- Immunalysis Zolpidem HEIA
Buprenorphine Urine HEIA
When compliance testing is the main objective of an application, getting an accurate screening result for buprenorphine is crucial. Highly specific to free buprenorphine and norbuprenorphine, this innovative immunoassay for the qualitative and semi-quantitative detection of buprenorphine shows virtually no cross-reactivity to frequently prescribed opiates and opioids. The antibody binds specifically and almost equally to free buprenorphine and its primary metabolite, norbuprenorphine.
This Buprenorphine assay provides excellent results in terms of precision (CV < 6 %), linearity (R = 0.9995), and sensitivity (sensitivity limit = 0.32 ng/mL) on the Beckman Coulter AU400 analyzer system. The assay provides a sensitive and specific screening method for buprenorphine in urine samples at a 5 ng/mL cut-off concentration.
Assay Characeristics
- Antibody specific to buprenorphine and norbuprenorphine
- Extremely low cross-reactivity to morphine and other opioids such as codeine, dihydrocodeine, tramadol, etc.
- Liquid, ready-to-use reagents, calibrators, and controls – no reconstitution
- Application protocols for all major clinical chemistry analyzers
- Flexible pack sizes tailored to your laboratory’s needs
Background
Buprenorphine is a semi-synthetic opioid derived from thebaine, a natural alkaloid of the opium poppy. It has a strong analgesic effect that is 25 to 40 times more effective than morphine. Buprenorphine has been used for several years now as medication for moderate to severe pain, in peri-operative analgesia, and for the treatment of heroin addiction in replacement therapy, particularly for the relief of withdrawal symptoms.
However, as with many potent substances, there is a downside: buprenorphine itself can also lead to addiction and harbors a high potential for abuse. A buprenorphine overdose may cause severe symptoms such as confusion, constricted pupils, hallucinations, hypotension, breathing difficulties, and even seizures and coma.
In the body, buprenorphine is converted to norbuprenorphine by N-dealkylation, followed by glucuronide conjugation of buprenorphine and norbuprenorphine. Interestingly, the amount of norbuprenorphine excreted in urine usually exceeds that of conjugated buprenorphine.
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